Course Overview

Skeletal Muscle Molecular Mechanics and the Fundamental Principles of Biological Motion
A 2.5 hour self-study Video Presentation by Prof. Pollack
Cost:  $79 CAD for 3-day viewing pass & Certificate of Attendance
CLICK HERE TO PURCHASE VIEWING PASS

Section I – Skeletal Muscle Molecular Mechanics
(1hr)

  • Skeletal muscle architecture
  • The sarcomere structure
  • The sliding-filament—cross-bridge theory
  • Testing the theory
  • Scientific evidence of filament shortening
  • Generators and sustainers of tension
  • The tension-length relation
  • Is the structure appropriate?
  • Thick filament structure
  • Thin filament structure
  • Contraction dynamics
  • Step size experiment confirmed
  • Scientific evidence of filament shortening
  • Thick and thin filament shortening


Section II – The Fundamental Principles of Biological Motion
(1.5hr)

  • Thick filament structure
  • The role of cell water in biology (the space is NOT empty)
  • The organization of cell water molecules
  • The Exclusion Zone (EZ); the fourth phase of water (a gel)
  • How EZ water differs from bulk water?
  • Charge separation, a battery!
  • The Exclusion Zone structure
  • Water, Charges, and Motion
  • Self-assembly principles
  • The role of cell water in muscle contraction
  • Skeletal muscle structure
  • Thick filament and water structure
  • Water order and disorder
  • Phase transition and muscle contraction
  • The energy that rebuilt the Exclusion Zone
  • Joints, gels, and the repulsive power of protons